Your Reliable and Agile Partner for Top Results

ProBioGen AG is a renowned Contract Development and Manufacturing Organization (CDMO) and technology provider. We perform cell line engineering, process development, and GMP manufacturing of biopharmaceuticals for clients in biotech and pharma. We offer proprietary innovative technologies for optimized biopharmaceutical manufacturing and analysis. ProBioGen also provides process development services and manufacturing technologies for viral vaccines.

Our additional new building houses 1000 L single-use bioreactor capacity to keep up with the ever-increasing demand from our clients. A second 1000 L single-use bioreactor is coming soon.

With over 25 years of experience in animal cell culture, combined with innovative scientific excellence and a strong intellectual property base, we cover the drug development value chain up to clinical phase III.

Our History

1994 – ProBioGen founded as a diagnostic company

2000 – Strategic shift towards therapeutic protein contract development and GMP manufacturing

2001 – Cell line development platform established

2002 – Manufacturing authorization granted, using single-use bioreactors right from the beginning

2003 – First client designer cell line developed

2005 – More than 15 patent families granted

2008 – First commercial license for AGE1.CR duck cell line

2010 – Strategic Investor: Minapharm Pharmaceuticals

2011 – First commercial license given for GlymaxX® ADCC enhancement technology

2013 – First product produced with ProBioGen CHO cell line entered the market

2016 – First product produced on AGE1.CR® duck cell line entered the market

2017 – More than 400 stable cell lines developed

2019 – Two facilities in Berlin-Weissensee

2019 – Launch of ProBioGen's DirectedLuck™ Transposase

2020 – Capacity increase with 1000L single-use bioreactor

2021 – Incorporation of the subsidiary MiGenTra GmbH

2022 – Three locations in Berlin-Weissensee

 

One-Stop-Shop

Global Customer Base

We are the partner of choice for biopharmaceutical companies relying on high quality cell line development and manufacturing capabilities. Our partners value our outstanding service quality, combined with variable project and deal structures, our quick responses and our flexibility.

Our clients benefit from custom-tailored projects designed to minimize development risks and ensure a successful outcome. Our experienced and flexible team of scientists, engineers, and technicians draws its motivation from the success of our clients’ projects. We are a reliable and agile partner in developing our clients’ products to the benefit of patients worldwide.

Our new building was recently refurbished to house 1000L single-use bioreactor lines to keep up with the ever-increasing demand from our clients.

Map

Company

  • Founded 1994 as a spin-off from the Charité (one of the largest university hospitals in Europe)
  • Located in Berlin, Germany
  • More than 300 employees
  • Subsidiary of Minapharm Pharmaceuticals SE, Egypt
  • Subsidiary MiGenTra incorporation

State-of-the-Art Services

  • GMP production cell lines
  • Upstream process development/ chemically-defined media platform
  • Downstream process development
  • Biosimilars & biobetters
  • Analytics/bioassays
  • Quality management

Key Technologies

  • ADCC enhancement
  • Genetic glyco-engineering
  • Transposase with Epigenetic Targeting
  • Human immunogenicity/ immunofunction testing
  • Productivity increase
  • Virus production systems
  • Chemically-defined media platform

Chiome Bioscience Inc.

Director, CMC Development

Quot Mark

"Because of ProBioGen's continuous support and always providing valuable information not only on technical challenges but also urgent issues associated with the project, our teams were able to bring a product from their facility into the clinic as scheduled, within several months here in Japan."

Celgene Corporation

Senior Director, Biologics Development

Quot Mark

"In ProBioGen, we see a company that values scientific contribution and enables high quality drug development for customers, which ultimately benefits the patients we all serve."

Pionyr Immunotherapeutics, Inc.

SVP, Technical Operations

Quot Mark

"In the midst of an escalating pandemic, ProBioGen successfully managed safety, staffing and procurement to maintain aggressive timelines for Pionyr's two first-in-class TME directed afucosylated monoclonal antibodies."

Executive Team

Since its foundation in 1994, ProBioGen has evolved from a research-based company into a fully grown, commercially successful biopharmaceutical organization. Apart from its cutting-edge, market-driven technologies, its success also lies in the dedication of its staff and, above all, the experience of its management team that brings a wealth of knowledge in the different areas of our day-to-day operations and an in-depth understanding of the trends and needs of the industry.

Dr. Lutz Hilbrich

Chief Executive Officer & Senator, Senate of Economy Europe

Dr. Lutz Hilbrich, Senator at Senate of Economy Europe, holds a Medical Degree from the… Read More

Dr. Gabriele Schneider

Chief Business Officer

Chief Business Officer since November 2017 following 10 years as Vice President Business… Read More

Andrea Hauptmann

Chief Financial Officer

Vice President Finance & Administration at ProBioGen since 2015 and Chief Financial Officer… Read More

Dr. René Brecht

Chief Operations Officer

Dr. René Brecht joined ProBioGen in 2002 and is Chief Operations Officer. René Brecht is… Read More

Dr. Volker Sandig

Chief Scientific Officer

Dr. Volker Sandig initiated ProBioGen’s cell line development program in 2000 resulting in… Read More

Dr. Marco Riedel

Senior Vice President, Head of Digital Transformation

Dr. Marco Riedel joined ProBioGen in 2000 and has held a number of management positions… Read More

Susanne Kästner

Senior Vice President, Quality

Ms. Susanne Kästner studied Chemistry at the Technical University in Berlin, Germany and… Read More

Julian Collins

Senior Vice President, Head of People & Organizational Development

Ms. Susanne Kästner studied Chemistry at the Technical University in Berlin, Germany and… Read More

Supervisory Board

The ProBioGen Supervisory Board oversees the Management Board and approves major corporate decisions. The Supervisory Board of ProBioGen AG comprises six members, with Dr. Wafik Bardissi, Chairman and Chief Executive Officer of the mother company Minapharm Pharmaceuticals, as Chairman.

Dr. Wafik Bardissi

Chairman

Dr. Wafik Bardissi has been working in the pharmaceutical and biopharmaceutical industry… Read More

Amr Shabrawishi

Co-Chairman

Amr Shabrawishi has been working in the medical, pharmaceutical, and biopharmaceutical… Read More

Prof. Dr.-Ing

Wiltrud Treffenfeldt

Prof. Dr.-Ing. Wiltrud Treffenfeldt is an experienced leader who has held several executive… Read More

Richard Chambers

Richard Chambers is an independent Corporate Finance Advisor and has been a member of the… Read More

Klaus Nestler

Klaus Nestler has been a Member of the Supervisory Board of ProBioGen AG since 2010. He is… Read More

Prof. Dr. med. Hans-Dieter Volk

Prof. Dr. med. Hans-Dieter Volk, MDPHD, trained Clinical Immunologist, was until 2021 the… Read More

Partners

The remarkable scientific progress in the last two decades has given rise to the development of new technologies at an unprecedented pace. We continuously screen the market and leverage our global network to identify and evaluate potential partners. Our partnerships are collaborative and target specific results, with a strong focus on value for our end customers.

Thermo Fisher Scientific

We engineered the Freedom™ CHO-S™ Kit platform, which enables cost-and-time-efficient stable cell line development for research and commercial purposes, in close collaboration with Thermo Fisher Scientific. The kit is available via Thermo Fisher Scientific.

Boehringer Ingelheim

Boehringer Ingelheim has a non-exclusive license for ProBioGen’s proprietary GlymaxX® ADCC enhancement technology (Antibody-Dependent Cell-Mediated Cytotoxicity). Under this license, Boehringer Ingelheim applies GlymaxX for third parties from its global contract manufacturing platform as well as to its own development candidates, to produce antibodies with enhanced ADCC potency.

References

Our customer range is extensive; some of our key customers and selected references are:

Bayer AG

Celgene Corporation

Chiome Bioscience Inc.

Luye Pharma Group

MedImmune, LLC

Surface Oncology Inc.

Tizona Therapeutics, Inc.

Valin Technologies Ltd.

References

Please feel free to contact us regarding our references. We are more than happy to connect you with relevant clients on an individual basis.

For further information please contact us at

Probiogen

Quality ManagementQuality Management

The high quality of ProBioGen’s products relies on the synergetic improvement of each individual process step. Our quality management system is based on standard DIN EN ISO 9001:2015 and specifically tailored to serve our client's individual requirements. ProBioGen holds a manufacturing authorization for GMP compliant manufacturing and batch release of biotechnological drug substances.
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